In the past years, a number of methods have been reported to be able to alleviate the symptoms of cognitive deficit induced by social isolation, including re-socialization (Maisonnette, Morato & Brandão, 1993), electro-acupuncture (Manni, Aloe & Fiore, 2009), and treatment with drugs such as citalopram, cariprazine, aripiprazole, acetylcysteine (NAC), selective blockade of dopamine D3 receptors, and selective mGluR2/3 agonist (Jones et al., 2011). The gene discussed is GRM2; the disease is Cognitive impairment.