Furthermore, as recently described for telomeres, mobility of chromosome internal double strand breaks (DSB) is mediated by 53BP1/SUN1/2 [p53 Binding Protein 1/(Sad1p, UNC 84 proteins 1 and 2)] and microtubules (Lottersberger et al., 2015) opening new perspectives for understanding DNA damage response defect in laminopathies. Here, TP53BP1 is linked to laminopathy.