Another HGPS-related LMNA mutation (E145K) in the central rod domain of Lamins A/C is associated with multilobulated nuclei and leads to alterations in pericentric chromatin, abnormal central clustering of centromeres, defects in the reassembly of the NE after mitosis or anaphase and mislocalization of telomeres (Taimen et al., 2009). This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.