ZMPSTE24 and mandibuloacral dysplasia: Recessive mutations in the ZMPSTE24 gene, encoding the Zinc Metallopeptidase STE24 that cleaves the prenylated and carboxy methylated 15-amino acid tail from the C-terminus of pre-Lamin A, are also associated with diseases that share features of accelerated aging such as MAD (Agarwal et al., 2003),or RD (Navarro et al., 2014).