TSHR and hyperthyroidism: Horie et al. genetically immunized NOD-H2(h4) or BALB/c mice with TSHR A-subunit, and found that IL-17 was indispensable for development of Graves’ hyperthyroidism in non-GD-susceptible NOD-H2(h4), but not in GD-susceptible BALB/c mice (68).