ZEB1 and cancer: Although miR-200c is known to repress ZEB1/ZEB2 to restore CDH1 expression in majority of the studies, there are reported findings that in some cancer cell lines, restoration of CDH1 expression is due to miR-200c gain of expression but the migration and invasiveness properties in those cell lines were still reduced (Cochrane et al., 2010; Pacurari et al., 2013).