Moreover, the absence of CDH1 gene expression in cancer can also imply that repression of CDH1 in cancer may be caused by other mechanisms such as C/A single nucleotide polymorphism at the promoter of CDH1 (Li et al., 2000; Wang et al., 2012) or due to CDH1 promoter hyper methylation (Caldeira et al., 2006; Shargh et al., 2014), in which both can suppress CDH1 expression. This evidence concerns the gene CDH1 and cancer.