CDH1 and neoplasm: However, the role of CDH1 as a tumor suppressor in ovarian cancer does not follow the classical EMT profile (Auersperg et al., 1999; Martin et al., 2011; Rodriguez et al., 2012), due to up-regulation of CDH1 expression observed in tumors that were derived from ovary (Auersperg et al., 1999), therefore more studies are needed to clarify the role of CDH1, miR-200c and other regulatory miRNAs, and their regulations of EMT/MET in ovarian cancer progression.