One of the major chloride channels, cystic fibrosis transmembrane conductance regulator (CFTR), has been shown to be responsible for the enterotoxin-induced secretory diarrhea in cholera and Travelers’ diarrhea (Chao et al., 1994; Grubb, 1995; Thiagarajah et al., 2004; Sonawane et al., 2007). Here, CFTR is linked to vibrio infectious disease.