ERBB4 and schizophrenia: Likewise, both NRG1 and its receptor ERBB4, which have been posited as promising candidates for schizophrenia as resulting from next-generation sequencing analyses (Agim et al., 2013; Hatzimanolis et al., 2013), enhance synchronized oscillations of neurons in the prefrontal cortex, known to be reduced in schizophrenia, via inhibitory synapses (Fisahn et al., 2009; Hou et al., 2014).