Overexpression of p190-B in MCF-10A cells results in reduced actin stress fiber network and exhibit circumferential staining for actin [24] and knockdown of p190-B decreases cell spread and migration in Huh-7 cells [17], suggesting a role for p190-B in regulating the signaling pathways that influence cancer cell migration and invasion. The gene discussed is ARHGAP5; the disease is cancer.