TP53 and neoplasm: As demonstrated in Fig. 8a, with the exception of HeLa control cells, the level of autophagy was downregulated in all investigated p53-deficient tumor cell lines (PANC-1, Jurkat, HL-60, U937) after 24 h indicated by less detectable MDC staining; mean fluorescence levels were found to range from ~31 to ~65 % lower in comparison to non-transfected but also SAHA-treated cells.