Although we found no significant evidence of an association between any of the SNPs in FKBP5 and MDD susceptibility when all samples were pooled, when one heterogeneous study was removed17, both the rs1360780 T-allele (Z = 2.95, P = 0.003, OR = 1.062, 95% CI 1.02–1.11) and the rs3800373 C-allele (Z = 3.05, P = 0.002, OR = 1.07, 95% CI 1.02–1.12) were significantly associated with MDD (Fig. 2). This evidence concerns the gene FKBP5 and major depressive disorder.