HMOX1 and non-small cell lung carcinoma: In the wild-type KEAP1 NSCLC cell lines H292 (Fig. 6a, b, *p < 0.001, **p < 0.05) and SKMES-1 (Fig. 6e, f, *p < 0.001, **p < 0.05), administration of the NRF2 activator over a 24-h period significantly increased the expression of the NRF2 downstream genes HO1, NQO1, and GCLM at the mRNA and protein levels.