We first sequenced the KEAP1 gene in four NSCLC cell lines to identify potential mutations and found that the A549 cell line harbors a G333C mutation within the first Kelch domain (KLD) (Fig. 1a) and that the H460 cell line harbors a D236H mutation in the intervention region (IVR) (Fig. 1b). This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.