PIK3CA and neoplasm: We clustered miRNAs according to the degree (proximity) of PI3K and MAPK pathways as well as cell cycle modulation upon their individual overexpression (Fig. 1B) (details are given in Methods section), and identified 23 potential tumor suppressor miRNAs negatively co-regulating PI3K, MAPK pathways and cell cycle progression (Supplementary Table 1).