We also observed predicted deleterious mutations in CREBBP histone acetyltransferase in 26% of the cases and we found a broad spectrum of mutations in other epigenetic genes previously described as frequently mutated in B-cell lymphomas like EP300, EZH2 and ARID1 (refs 12, 13, 14). The gene discussed is EZH2; the disease is B-cell non-Hodgkin lymphoma.