TARDBP and frontotemporal dementia: Transactive DNA-binding protein 43 kDa (TDP-43) is the major component of inclusions in motor neurons of sALS and some cases of FTLD [4, 54], and mutations to its corresponding gene, TARDBP, are responsible for a small number of both fALS and sALS cases [27, 75], as well as FTD.