It is currently unknown if MLC-2-dependent actomyosin activity could be linked to the Wnt/β-catenin pathway; however, there is a literature report from Samuel et al. implicating actomyosin-mediated cellular contractile force with tissue stiffness and increased activation of β-catenin (a known mechanically activated transcription factor) to force tumour progression in a mouse model of skin cancer66. Here, MYL2 is linked to neoplasm.