When used as add-on therapy to metformin, liraglutide significantly increased the risk of gastrointestinal disorders (RR = 1.59, 95%CI: 1.15, 2.19; P = 0.005) compared with control (placebo, dulaglutide, sitagliptin, glimepiride, NPH, and insulin glargine). The gene discussed is INS; the disease is digestive system disorder.