GLP1R and Hypoglycemia: Moreover,GLP-1 also reduces the risk of hypoglycaemia since its activities in the glucose-lowering are glucose dependent8.However, GLP-1 is rapidly metabolized and inactivated by the protease dipetidyl peptidase-4 (DPP-4)9, which leads to a very short half-life and limits its therapeutic potential in the clinical practice10.