Using a liver TMA generated from 179 HCC and matched non-tumorous liver blocks, Cheng et al. [44] reported that expression of a histone-lysine N-methyltransferase, EZH2 (Enhancer Of Zeste Homolog 2), is significantl associated both with the nuclear and cytoplasmic β-catenin expression. Here, EZH2 is linked to hepatocellular carcinoma.