ApoAIV and adiponectin show anti-atherogenic and antioxidative properties and arenegatively correlated with cardiovascular disorders16, 17.Adiponectin probably protects against cardiac remodeling by attenuating myocardialhypertrophy18; furthermore, it also has protective effectsagainst different vascular disorders, such as endothelial dysfunction andhypertension, and inhibits platelet aggregation and inflammation (reviewed by ref.19). This evidence concerns the gene APOA4 and endothelial dysfunction.