Four genes in particular, MALAT1, CLCN5, MLL3, and SLC25A36, that were up-regulated in metastatic prostate cancer compared to primary prostate cancer were also displayed an enhanced expression in PC3-WT osteoblast co-cultures and PC3-SostKO osteoblast co-cultures compared to PC3 alone (Figure 3B). The gene discussed is CLCN5; the disease is metastatic prostate carcinoma.