CCN2 and cancer: Of all the differentially expressed genes, secreted signaling proteins Tgfb2, Il-6, Cxcl1, and Ctgf and metallopeptidases Mmp13, Adamts4, and Adamts5 were of particular interest, as these genes have previously been shown to play a role in regulating cancer migration and invasion [29,30,31,32,33,34,35,36] and bone remodeling [37,38,39,40,41].