Microarray revealed that MALAT1 was up-regulated in prostate cancer cells co-cultured with WT osteoblasts compared to PC3 alone, suggesting that factors secreted by osteoblasts up-regulate MALAT1. Subsequently, we co-cultured PC3 cells with UMR osteoblasts and, using qPCR, confirmed that the factors secreted by osteoblasts up-regulated MALAT1 expression in prostate cancer. The gene discussed is MALAT1; the disease is Familial prostate cancer.