An integrated network of Tgfb2, Il-6, Cxcl1, and Ctgf interactions revealed several putative binding partners in osteoblasts and/or prostate cancer and suggested that these secreted cytokines may control up-regulated transcription factors Junb, Cebpb and Stat3 in osteoblasts (Figure 2). The gene discussed is CCN2; the disease is prostate cancer.