The triple-combination array has detected many genes, including bleomycin hydrolase gene (BLMH), estrogen receptor 1 gene (ESR1), dynamin 3 (DNM3), doublecortin domain-containing 2 (DCDC2), collagen type 1 alpha 1 gene (COL1A1), protein tyrosine kinase 7 (PTK7), and cyclin J (CCNJ) as candidate cancer-related genes in HCC [94,95,96,97,98,99,100]. The gene discussed is ESR1; the disease is cancer.