Using this double-combination array, many important genes have been detected, including metallothionein 1G (MT1G), epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1), A kinase anchor protein 12 (AKAP12), and leukemia inhibitory factor receptor (LIFR) genes as tumor suppressor genes in hepatocellular carcinoma, and reelin (RELN) as a key regulatory gene associated with the recurrence of HCC [88,89,90,91,92]. The gene discussed is EFEMP1; the disease is hepatocellular carcinoma.