CCN2 and campomelic dysplasia: These included regulator of G-protein signaling 4 (RGS4) and 7 (RGS7), which were both upregulated by CCG-1423, and CTGF (connective tissue growth factor), and SOX9 (sex determining region Y-box 9, also referred to as campomelic dysplasia, autosomal sex reversal) which were down-regulated.