TGM2 and neoplasm: Since TGM2 with its multifunctional role could represent an interesting candidate, after confirming the up-regulation of the gene with an orthogonal assay, we evaluated whether in our activated fibroblasts its up-modulation affected the intracellular or the secreted encoded protein or both, and confirmed that treatment with tumor cell-derived conditioned medium was responsible for an increase in the secreted protein.