The genomic changes in adult ALL were comparable to those identified in pediatric ALL, including deletions of 3p14.2 (FHIT), 5q33.3 (EBF), 6q, 9p21.3 (CDKN2A/B), 9p13.2 (PAX5), 13q14.2 (RB1), and 17q11.2 (NF1). This evidence concerns the gene CDKN2A and acute lymphoblastic leukemia.