In southern MS patients, DRB1*04:05 carriers were younger and had an earlier onset, longer disease duration, lower EDSS and MSSS scores, and lower frequencies of Barkhof brain lesions and CSF IgG abnormalities than non-DRB1*04:05 carriers (p = 0.0334, p = 0.0001, p = 0.0133, p = 0.0263, p = 0.0021, p = 0.0143, and p = 0.008, respectively). Here, HLA-DRB1 is linked to myeloid sarcoma.