Overall net reclassification improvements for NT-proBNP concentration across predicted 10 year risk categories defined by the 2013 ACC and AHA guidelines1 were 0·027 (0·019–0·036) for the combination of coronary heart disease and stroke and 0·028 (0·019–0·038) for the combination of coronary heart disease, stroke, and heart failure (table). The gene discussed is NPPB; the disease is Stroke.