Indeed, tubulointerstitial fibrosis is considered an important predictor of renal survival 30 and TGFβ1 is a key pro‐fibrotic cytokine that contributes to renal fibrosis 31, 32, 33, while TWEAK is a key pro‐inflammatory cytokine which promotes glomerular and tubulointerstitial inflammation and fibrosis 12. The gene discussed is TNFSF12; the disease is renal fibrosis.