Considering that c-Myc and survivin, target genes of both BCR/ABL and Hippo-YAP pathways which are associated with the regulation of cell proliferation, are involved in the progression and response to IM in CML [34–37], the role of YAP in the pathogenesis of CML may be interesting to explore. The gene discussed is MYC; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.