NFKB1 and cancer: Dox, as a widely used chemotherapy reagent in different types of cancer, triggers the apoptosis of cancer cells by interfering the DNA topoisomerase ‖α and creating DNA double-stand breaks which subsequently activates NF-κB signaling pathway in order to repair the damage via a stimulatory action on homologous repair, involving the targets ATM and the tumor suppressor gene, breast cancer susceptibility gene 2 (BRCA2)7, 32.