LCLs from 15 familial breast and ovarian cancer (Table 1) including four BRCA1-positive, 2 BRCA2-positive, 1 CHK2-positive and 8 BRCA1/2/CHK2/PALB2-negative LCLs were analyzed by the p53-MCL test. The gene discussed is BRCA1; the disease is Hereditary breast and ovarian cancer syndrome.