BRCA1 and Hereditary breast and ovarian cancer syndrome: In particular BRCA1 pathogenic mutation recurred in about 26 % (8/30) of the Hereditary Breast and Ovarian Cancer (HBOC) families and in about 7 % (4/60) of the Hereditary Breast Cancer (HBC) families, while BRCA2 pathogenic mutation occurred in about 13 % (4/30) and 7 % (4/60) of the HBOC and HBC families, respectively.