MDM2 and viral infectious disease: For instance, alterations in the splicing patterns of RFX5, which encodes for a protein involved in MHC-II expression, MDM2, a key cellular component of the signaling pathway used by reovirus for infection, and RFN135, which encodes a RING finger protein involved in the RIG-I/MDA5-mediated induction of IFN-alpha/beta pathways were observed upon viral infection.