Sickle cell disease is an inherited red blood cell (RBC) disorder that arises from the mutation of the 6th amino acid in the beta chain of hemoglobin (Hb) from glutamic acid to a valine [1], promoting polymerization of the mutated Hb under hypoxic conditions and premature denaturation of the protein during circulation. This evidence concerns the gene GSTM1 and sickle cell disease.