Visentin and cols., in a study examining relationships between levels of adipokines (adiponectin and leptin), inflammatory markers (CRP, TNF-a and IL-6) and vascular remodeling in pregnancies with intrauterine growth restriction, found higher CIMT values, high serum concentrations of proinflamatory cytokines (leptin, hsCRP, TNF-a and IL-6) and low levels of adiponectin in fetuses (42). The gene discussed is TNF; the disease is fetal growth restriction.