MEIS1 and Anxiety: However, in silico analyses by the use of Regulome database suggested that RAPGEF4 SNP rs17746510 falls in highly conserved consensus-binding sequences (TGACAG) of transcription factors such as MEIS1 (myeloid ecotropic viral integration site 1).93 Interaction between MEIS1 and Evolutionary Conserved Regions 1 enhancer regulates the tissue-specific expression of neuropeptides such as substance P in the central amygdala,94 which has a role in the modulation of fear and anxiety.