In the present study, Epac wild-type (WT), Epac1−/−, Epac2−/− and Epac1;Epac2 double knockout (Epac1−/−;2−/−) mice were used to investigate the roles of Epac in anxiety and depressive disorders, as well as cognitive deficits. Here, RAPGEF4 is linked to Cognitive impairment.