Similar criteria were associated with a higher risk on an SAE: a history of decompensated liver disease (RR 1.81), platelet count (RR 1.45), albumin (RR 2.03), bilirubin (RR1.89), hemoglobin (RR 1.72), malignancy (RR 2.31) and presence of cardiac disease (RR 1.97). This evidence concerns the gene ALB and heart disorder.