SETD7 and infection: Instead, we find that epithelial turnover is affected by the lack of Setd7, and therefore, IEC turnover can be dominant over adaptive immune responses in terms of importance for resistance to T. muris. In Setd7ΔIEC mice we observed higher turnover during homeostasis compared to Setd7f/f mice, demonstrating that SETD7 regulates IEC turnover independently of infection-induced immune cell cues.