Ovalbumin (OVA)-primed and inhalation-challenged asthma model mice with MIF deficiency had a reduction in the total and OVA-specific IgE [26], whereas MIF−/− mice infected with Schistosoma mansoni [35] or Taenia crassiceps [36] produced normal amounts of Th2 cytokines and IgE. Here, IGHE is linked to asthma.