These polymorphisms in the MIF gene are also associated with several immune-mediated inflammatory diseases, including atopy [12], asthma [13], juvenile idiopathic arthritis [9], rheumatoid arthritis[11], psoriasis [14, 15], and psoriatic arthritis [10, 16], suggesting that the polymorphisms are functionally important. Here, MIF is linked to juvenile idiopathic arthritis.