Similarly, in diabetic subjects, the density of NRP-1 positive vessels was not different from the density seen in healthy controls (p = 0.30; 104.4+/-54.1/mm2), for those who are asymptomatic for neuropathy (DM Type 1 (68.4+/-36.0/mm2; DM Type 2 (110.3+/-42.4/mm2) and those with diabetic polyneuropathy (DM Type 2 NP+: 100.3+/-84.7/mm2) (Fig 7C). This evidence concerns the gene NRP1 and diabetic polyneuropathy.