In addition, mice lacking vesicular glutamate transporter 2 (Vglut2) in SF-1 neurons exhibited a modest increase in body weight when exposed to high fat diet (HFD) and also developed hypoglycemia during fasting due to impaired induction of the glucose raising hormone glucagon and the gluconeogenic enzymes PEPCK and G6Pase [14]. This evidence concerns the gene GCG and Hypoglycemia.