Deletion of Vglut2 in SF-1 neurons in the VMH was reported to cause obesity under high fat diet associated with hyperphagia and increased adiposity accompanied by hypoglycemia specifically in fasted condition, indicating that Vglut2 plays a role in regulating energy balance in the VMH [14]. The gene discussed is SLC17A6; the disease is obesity due to melanocortin 4 receptor deficiency.