For example, a search of the P/PA databases for LGK974, a potent inhibitor of the Wnt secretion protein Porcupine [13] identified by researchers at Novartis only turned up in PA by Novartis (PA# 20150125857 “Cancer Patient Selection for administration of Wnt Signaling inhibitors using RNF43 status”). Here, RNF43 is linked to cancer.