For example, an association between blood pressure and REE has been reported in Nigerians and African Americans [45], higher fasting serum insulin is associated with increased REE in patients who are non-diabetic and have schizophrenia [21], hyperglycemia and glycemic intolerance were associated with an increase in REE in patients with type 2 diabetes [22,23,24], high vegetable fats intake is associated with high REE in vegetarians [26], and REE was increased by dietary protein during overfeeding [25]. This evidence concerns the gene INS and schizophrenia.