NOS3 and atherosclerosis: In the transcriptomic analysis in the PREDIMED study [56] carried out in a subsample after a three-month intervention with MedDiets in comparison with the control group, we detected that the key pathways in the physiopathology of cardiovascular events, such as atherosclerosis, renin-angiotensin, nitric oxide and angiopoietin signaling, were modulated by MedDiet + EVOO, whereas hypoxia and endothelial nitric oxide synthases (eNOS) signaling pathways were modified by both MedDiet; while none of the pathways were modulated by the control group in blood cells.