A previous study demonstrated that GATA6 is an important transcription factor in the transactivation of TFF1/2 in gastric cancer [9]; however, the current study may provide mechanistic evidence to explain how TFF1 and TFF2 are downregulated by epigenetic silencing of GATA6 through the activation of JAK/STAT signaling in gastric cancer. The gene discussed is TFF2; the disease is gastric cancer.