APOE and early-onset autosomal dominant Alzheimer disease: A further stratified analysis of the association between CHAT rs3810950 allele and Alzheimer's disease according to the ApoE-ε4 status showed that, with the same rs3810950 polymorphism, ApoE-ε4 carriers exhibited a significantly higher incidence of AD than the non-ApoE-ε4 carriers (Table 4).