Specimen 2 consists of two morphologically different tumor nodules, an invasive adenocarcinoma, solid predominant type [8] (Figure 2(c)), which is positive for BRAF V600E mutation (Figure 1(f)) and a minimally invasive adenocarcinoma, nonmucinous tumor (Figure 2(d)), which is negative for BRAF codon 600 mutation (Figure 1(e)). This evidence concerns the gene BRAF and adenocarcinoma.