Other studies have shown that some core (ND4, ND5, NDUFS1, NDUFS2, and NDUFV1) and accessory (NDUFB5, NDUFB6, and NDUFB7) subunits are oxidatively damaged in PD brains, resulting in CI misassembling and functional impairment (Keeney et al., 2006). This evidence concerns the gene NDUFS1 and Parkinson disease.