This was noted in studies of MET amplified lung cancer cells, which demonstrated that the formation of EGFR:MET (Mueller et al., 2010; Tanizaki et al., 2011) and ErbB2:MET (Tanizaki et al., 2011) heterodimers rendered the EGFR family member resistant to dephosphorylation in the presence of their respective TKI (Tanizaki et al., 2011). This evidence concerns the gene MET and lung cancer.