EGFR and lung carcinoma: This was noted in studies of MET amplified lung cancer cells, which demonstrated that the formation of EGFR:MET (Mueller et al., 2010; Tanizaki et al., 2011) and ErbB2:MET (Tanizaki et al., 2011) heterodimers rendered the EGFR family member resistant to dephosphorylation in the presence of their respective TKI (Tanizaki et al., 2011).