HOXB7 and interstitial nephritis: Furthermore, autoantibodies targeting kidney collecting ducts specific antigens [aquaporin 2 (AQP2) and two transcription factors regulating the aquaporin 2 promoter, namely homolog of the human homeobox B7 (HOXB7) and NF of activated T cells 5 (NFAT5)], have been recently identified in APECED patients affected with tubulointerstitial nephritis (76).