Finally, as the functional role of DNA methylation in non-CpG sites such as enhancers and gene bodies are largely unknown, how TET2 or IDH1/2 mutations lead to leukemia promoting transcriptional changes through hypermethylation in these sites is unclear; while TET2 was found to be significantly enriched with H3K4me1 and transcription factor p300 at the enhancer regions (131), whether TET2 is required for establishing these enhancers marks, whether mutant TET2 changes the behavior of these cis regulatory regions, and how this ultimately perturbs transcriptional networks is still unexplored. Here, TET2 is linked to leukemia.