KMT2A and leukemia: While Ono and colleagues were the first to clone the gene and named it LCX (leukemia-associated protein with a CXXC domain) (106); Lorsbach et al. (107) cloned the same partner of the MLL translocation and named it TET for Ten-Eleven Translocation owing to its frequent MLL fusion [t(10;11)(q22;q23)] in AML.