Consistent with this idea is the finding that in inducible mouse deletion models of Dnmt3a, HSPC have mild phenotypic changes such as impaired differentiation, increased self-renewal, and occasionally transform to a myeloproliferative disease, but do not show robust changes in DNA methylation patterns or correlation between methylation changes and gene expression profiles (98–101). This evidence concerns the gene DNMT3A and myeloproliferative disorder.