SIX4 and Insulin resistance: Furthermore, the nuclear level of Six4 and Six5 homeoproteins, both expressed in adult myofibers, might be higher in SOL of ciSix1 than in cSix1. In adult muscles, the Six4-Baf60c transcription complex controls Deptor expression and transgenic animals with muscle-specific forced expression of Deptor show a switch from oxidative to glycolytic metabolism and are protected from diet-induced insulin resistance [77].