IL17A and systemic lupus erythematosus: Furthermore, the expansion of Th17 cells and overproduction of IL-17 may further aggravate lupus injury, as IL-17 can amplify the immune response by inducing the local production of chemokines and cytokines, recruiting neutrophils and monocytes, augmenting the production of autoantibodies, and aggravating the inflammation and damage of target organs, such as the kidney, in SLE.