Both metabolic and Cushing's syndrome human phenotypes [30, 31] share hyperuricemia, and it has been claimed that this high uric acid peripheral level may have a key pathogenic role in several metabolic syndrome phenotypes [32], because, among others, uric acid peripheral levels correlate well with those of insulin and triglycerides in fructose-induced metabolic syndrome and, interestingly, correcting the IR state the hypertriglyceridemia and hyperuricemia can be overridden [32]. The gene discussed is INS; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.